Chemistry Heterocyclic Building Blocks Pyridines ethyl 4,6-dichloronicotinate
Ambeed provide 4 derivatives of ethyl 4,6-dichloronicotinate.
These compounds have the same murcko framework: ethyl 4,6-dichloronicotinateNucleophilic Substitution: The chlorine atoms present in the molecule can undergo substitution reactions with nucleophiles. For instance, nucleophilic substitution by hydroxide ion can result in the formation of ethyl 4,6-dihydroxynicotinate.
Ester Hydrolysis: The ester linkage can undergo hydrolysis under acidic or basic conditions, leading to the formation of ethyl 4,6-dichloronicotinic acid or its conjugate base.
Reduction: The compound can be reduced to form ethyl 4,6-dichloronicotinamide or other reduced derivatives using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Grignard Reaction: The compound can react with Grignard reagents to form more complex molecules through nucleophilic addition reactions.
Halogenation: The chlorine atoms present in the molecule can undergo further halogenation reactions under appropriate conditions, leading to the formation of compounds with additional halogen atoms substituted at different positions.
Coupling Reactions: The compound can participate in various coupling reactions, such as Suzuki coupling or Heck coupling, to form biaryl compounds or other coupled products.
Oxidation: Under certain conditions, ethyl 4,6-dichloronicotinate can undergo oxidation to form corresponding carboxylic acid or other oxidized products.
Esterification: The compound can undergo esterification reactions with alcohols under acidic conditions to form different esters.
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