Chemistry Heterocyclic Building Blocks Pyrimidines ethyl 4-chloropyrimidine-5-carboxylate
Ambeed provide 5 derivatives of ethyl 4-chloropyrimidine-5-carboxylate.
These compounds have the same murcko framework: pyrimidine
Nucleophilic Substitution: The chlorine atom in the 4-position can be replaced by a nucleophile (e.g., substitution with hydroxide ion or amines) to form a substituted product.
Acylation Reactions: The carboxylic ester group in the molecule can undergo acylation reactions, such as reactions with acyl chlorides or anhydrides, to form amides or other derivatives.
Reduction: The carbonyl group in the ester can be reduced to the corresponding alcohols using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Ester Hydrolysis: The ester linkage can undergo hydrolysis in the presence of an acid or a base to form the corresponding carboxylic acids or its salt.
Cyclization: Depending on the reaction conditions, cyclization reactions may occur, leading to the formation of cyclic compounds.
Cross-Coupling Reactions: The compound can be involved in cross-coupling reactions with various coupling partners, such as Suzuki-Miyaura coupling or Heck coupling, in the presence of appropriate catalysts.
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Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate
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Ethyl 4-chloro-6-methylpyrimidine-5-carboxylate
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Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate
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Ethyl 4,6-dichloropyrimidine-5-carboxylate