Chemistry Heterocyclic Building Blocks Pyridines isonicotinic acid
Ambeed provide 23 derivatives of isonicotinic acid.
These compounds have the same murcko framework: isonicotinic acidAcid-Base Reactions: Isonicotinic acid can undergo acid-base reactions due to the presence of the carboxylic acid group. It can react with bases to form salts, and with strong bases to undergo deprotonation.
Esterification: Isonicotinic acid can undergo esterification reactions with alcohols to form esters. The carboxylic acid group reacts with the hydroxyl group of the alcohol in the presence of an acid catalyst to yield the ester.
Amide Formation: Isonicotinic acid can react with amines to form amides. The carboxylic acid group reacts with the amine group of the amine to form an amide linkage.
Substitution Reactions: The pyridine ring in isonicotinic acid is susceptible to electrophilic aromatic substitution reactions, where the aromatic ring can undergo substitution reactions with electrophiles.
Decarboxylation: Under certain conditions, isonicotinic acid can undergo decarboxylation, where the carboxylic acid group is removed from the molecule, yielding the corresponding substituted pyridine.
Oxidation Reactions: Isonicotinic acid can undergo oxidation reactions to yield various oxidation products, depending on the conditions and reagents used.
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3-(Trifluoromethoxy)isonicotinic acid
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2-(((tert-Butoxycarbonyl)amino)methyl)isonicotinic acid
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3-Fluoro-2-(trifluoromethyl)isonicotinic acid
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5-Bromo-2-(trifluoromethyl)isonicotinic acid
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2-(2-(Propan-2-ylidene)hydrazinyl)isonicotinic acid
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5-((tert-Butoxycarbonyl)amino)-2-fluoroisonicotinic acid