Chemistry Heterocyclic Building Blocks Pyridines isonicotinonitrile
Ambeed provide 16 derivatives of isonicotinonitrile.
These compounds have the same murcko framework: isonicotinonitrileNucleophilic substitution: Isonicotinonitrile can undergo nucleophilic substitution reactions at the carbon atom adjacent to the cyano group (-CN), particularly with strong nucleophiles such as amines or organometallic reagents.
Addition reactions: It may undergo addition reactions with strong electrophiles, such as acids or alkylating agents, at the carbon atom of the nitrile group.
Metalation reactions: Isonicotinonitrile can be metalated at the α-position to the nitrile group, leading to the formation of organometallic complexes, which can then participate in various organic transformations.
Redox reactions: It may participate in redox reactions, either as an oxidant or a reductant, depending on the reaction conditions and the nature of the other reactants involved.
Cyclization reactions: Under certain conditions, isonicotinonitrile can undergo intramolecular cyclization reactions, leading to the formation of cyclic compounds.
Substitution reactions: It can undergo substitution reactions at the pyridine ring, particularly under harsh conditions or with strong reagents.
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5-Bromo-2-(trifluoromethyl)isonicotinonitrile