Chemistry Heterocyclic Building Blocks Pyridines methyl 2-(pyridin-2-yl)acetate
Ambeed provide 9 derivatives of methyl 2-(pyridin-2-yl)acetate.
These compounds have the same murcko framework: methyl 2-(pyridin-2-yl)acetateHydrolysis: Esters can undergo hydrolysis in acidic or basic conditions to give the corresponding carboxylic acids and alcohols. In the case of methyl 2-(pyridin-2-yl)acetate, hydrolysis would yield pyridine-2-carboxylic acid and methanol.
Esterification: It can undergo esterification reactions with alcohols in the presence of acid catalysts, yielding different esters.
Grignard Reaction: Methyl 2-(pyridin-2-yl)acetate can react with Grignard reagents to form ketones.
Reduction: It can be reduced to the corresponding alcohols using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Acylation: The pyridine nitrogen can undergo acylation reactions with acyl chlorides or anhydrides to yield N-acyl pyridinium derivatives.
Ring substitution reactions: The pyridine ring can undergo various substitution reactions, such as electrophilic aromatic substitution, nucleophilic aromatic substitution, etc., depending on the reaction conditions and reagents used.
Oxidation: It can undergo oxidation to form the corresponding carboxylic acids using strong oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4).
Decarboxylation: Under certain conditions, esters can undergo decarboxylation reactions to give the corresponding ketones and carbon dioxide.
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Methyl 2-(4-methylpyridin-2-yl)acetate
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(6-(2-Methoxy-2-oxoethyl)pyridin-3-yl)boronic acid