Chemistry Heterocyclic Building Blocks Pyridines methyl 2-chloroisonicotinate
Ambeed provide 11 derivatives of methyl 2-chloroisonicotinate.
These compounds have the same murcko framework: methyl 2-chloroisonicotinateNucleophilic substitution: The chlorine atom in the 2-position can be replaced by a nucleophile, such as a primary amine or a thiol, leading to the formation of corresponding substitution products.
Ester hydrolysis: Under basic or acidic conditions, the ester bond in methyl 2-chloroisonicotinate can undergo hydrolysis to form the corresponding carboxylic acid and methanol.
Reduction: The carbonyl group in methyl 2-chloroisonicotinate can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Cyclization: Depending on the reaction conditions and reagents, methyl 2-chloroisonicotinate can undergo cyclization reactions to form heterocyclic compounds, especially pyridine derivatives.
Cross-coupling reactions: Methyl 2-chloroisonicotinate can participate in cross-coupling reactions with various organometallic reagents (e.g., Grignard reagents, organozinc reagents) to form biaryl or heteroaryl compounds.
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Methyl 2-chloro-3-(trifluoromethyl)isonicotinate
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Dimethyl 2-chloropyridine-3,4-dicarboxylate
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Dimethyl 6-chloropyridine-3,4-dicarboxylate
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Methyl 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylate