Chemistry Heterocyclic Building Blocks Pyridines methyl 2-chloronicotinate
Ambeed provide 6 derivatives of methyl 2-chloronicotinate.
These compounds have the same murcko framework: methyl 2-chloronicotinateNucleophilic Substitution: The chlorine atom is susceptible to nucleophilic substitution reactions. For instance, it can be replaced by nucleophiles such as hydroxide ions (in basic conditions) or primary amines to form corresponding hydroxy or amino derivatives.
Ester Hydrolysis: The ester functionality can undergo hydrolysis in acidic or basic conditions to yield the corresponding carboxylic acid and methanol.
Grignard Reaction: Methyl 2-chloronicotinate can react with Grignard reagents to form substituted pyridines.
Reduction: The ester group can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Acylation: The methyl ester group can undergo acylation reactions with acyl halides or acid anhydrides to form amides.
Oxidation: The methyl group can be oxidized to a carboxylic acid group, typically under harsh oxidative conditions.
Alkylation: The pyridine ring can undergo alkylation reactions with alkyl halides in the presence of a base.
Cyclization: It can undergo cyclization reactions under certain conditions to form fused heterocyclic compounds.
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Methyl 2-chloro-5-(trifluoromethyl)nicotinate