Chemistry Heterocyclic Building Blocks Pyridines methyl 6-bromonicotinate
Ambeed provide 6 derivatives of methyl 6-bromonicotinate.
These compounds have the same murcko framework: methyl 6-bromonicotinateSubstitution Reactions: The bromine atom in the 6-position of the pyridine ring can undergo substitution reactions with various nucleophiles or electrophiles. For instance, nucleophilic substitution reactions can replace the bromine with other nucleophiles such as amines or alkoxides.
Ester Hydrolysis: Methyl esters like methyl 6-bromonicotinate can undergo hydrolysis in the presence of acidic or basic conditions, leading to the formation of the corresponding carboxylic acid and alcohol.
Coupling Reactions: The bromine atom can participate in coupling reactions such as Suzuki coupling or Stille coupling, enabling the synthesis of more complex molecules through C-C bond formation.
Reduction Reactions: The ester group can be reduced to an alcohol group using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation Reactions: The methyl 6-bromonicotinate can undergo oxidation reactions under suitable conditions, converting it into various oxidation products depending on the reagents and reaction conditions employed.
Cyclization Reactions: The compound can undergo cyclization reactions under certain conditions, forming fused or spirocyclic ring systems.
Metal Complexation: The bromine atom can act as a ligand for metal ions, leading to the formation of metal complexes with potential applications in catalysis or coordination chemistry.
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