Chemistry Heterocyclic Building Blocks Pyridines methyl 6-fluoronicotinate
Ambeed provide 4 derivatives of methyl 6-fluoronicotinate.
These compounds have the same murcko framework: methyl 6-fluoronicotinateNucleophilic Substitution: Due to the presence of the fluorine atom, the compound can undergo nucleophilic substitution reactions where the fluorine is replaced by a nucleophile. This could lead to the formation of various substituted derivatives of nicotinic acid.
Acid-Base Reactions: Methyl 6-fluoronicotinate can undergo acid-base reactions, where the acidic proton on the carboxylic acid group can be deprotonated by a base to form the corresponding carboxylate ion.
Esterification: The carboxylic acid group in methyl 6-fluoronicotinate can undergo esterification reactions with alcohols in the presence of an acid catalyst, forming methyl esters of nicotinic acid derivatives.
Reduction: The compound may undergo reduction reactions where the double bond between the carbon and oxygen in the carboxyl group could be reduced, resulting in the formation of a primary alcohol.
Aromatic Substitution: The aromatic ring in methyl 6-fluoronicotinate can undergo electrophilic aromatic substitution reactions, where a substituent is added onto the aromatic ring under appropriate conditions.
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Methyl 6-fluoro-4-(isopropylamino)pyridine-3-carboxylate
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Methyl 6-fluoro-4-(methylamino)pyridine-3-carboxylate
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Methyl 4-(ethylamino)-6-fluoropyridine-3-carboxylate