Chemistry Heterocyclic Building Blocks Pyridines methyl isonicotinate
Ambeed provide 16 derivatives of methyl isonicotinate.
These compounds have the same murcko framework: methyl isonicotinateEster Hydrolysis: Methyl isonicotinate can undergo hydrolysis in the presence of acid or base to form isonicotinic acid and methanol.
Esterification: It can react with alcohols in the presence of acid catalysts to form esters.
Nucleophilic Substitution: The ester functionality can undergo nucleophilic substitution reactions with nucleophiles such as amines or thiols, resulting in the displacement of the methoxy group.
Aromatic Substitution: The aromatic ring can undergo electrophilic aromatic substitution reactions, such as nitration, halogenation, or Friedel-Crafts acylation/alkylation.
Reduction: The carbonyl group of the ester can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride or sodium borohydride.
Oxidation: The methyl group can be oxidized to a carboxylic acid using strong oxidizing agents like potassium permanganate or chromic acid.
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2,4-Pyridinecarboxylic acid, 4-methyl ester
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Methyl 5-bromo-2-(trifluoromethyl)isonicotinate