Chemistry Heterocyclic Building Blocks Pyridines N,N-dimethylpyridin-4-amine
Ambeed provide 6 derivatives of N,N-dimethylpyridin-4-amine.
These compounds have the same murcko framework: N,N-dimethylpyridin-4-amineAcylation: N,N-dimethylpyridin-4-amine can undergo acylation reactions, where an acyl group is added to the nitrogen atom. This can be achieved using acyl chlorides or acid anhydrides in the presence of a base like pyridine.
Alkylation: The amine group can undergo alkylation reactions, where an alkyl group is added to the nitrogen atom. alkyl halides or alkyl sulfates are commonly used as alkylating agents, often in the presence of a base.
Amination: N,N-dimethylpyridin-4-amine can be further aminated, introducing additional amine groups. This can be achieved using reagents such as ammonia or primary or secondary amines under suitable conditions.
Oxidation: The nitrogen atom in the amine group can be oxidized to form an N-oxide or other oxidized derivatives. Oxidizing agents such as hydrogen peroxide or peracids can be used for this purpose.
Reduction: Conversely, the nitrogen atom can be reduced back to the amine or further reduced to form amines with fewer alkyl groups attached. Reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) are commonly employed for these transformations.
Substitution reactions: The aromatic ring can undergo substitution reactions, such as electrophilic aromatic substitution (EAS) or nucleophilic aromatic substitution (SNAr), depending on the nature of the substituent and the reaction conditions.
Condensation reactions: It can undergo condensation reactions with carbonyl compounds or other nucleophiles to form Schiff bases or other related compounds.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
4-Dimethylaminopyridinium bromide perbromide