Chemistry Organic Building Blocks Aryls N-((5R,6R)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)-2-phenylacetamide
These compounds have the same murcko framework: N-((5R,6R)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)-2-phenylacetamide.
Hydrolysis: The amide bond can undergo hydrolysis, typically under acidic or basic conditions, to yield the corresponding carboxylic acid and amine.
Reduction: The carbonyl group in the acetamide moiety can be reduced to an alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Acylation: The amine group can be acylated using various acylating agents to form amide or imide derivatives.
Cyclization Reactions: The compound contains a thia-azabicyclic ring system, which can participate in various cyclization reactions under appropriate conditions.
Substitution Reactions: Depending on the conditions, the phenyl group and the thia-azabicyclic ring may undergo substitution reactions with appropriate electrophiles or nucleophiles.
Oxidation: The sulfur atom in the thia-azabicyclic ring can be oxidized to form sulfoxides or sulfones under oxidative conditions.
Enzymatic Reactions: Depending on the specific stereochemistry and functional groups, enzymatic reactions such as hydrolysis or reduction may be possible.
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