Chemistry Organic Building Blocks Fluorinated Building Blocks N-(3-fluorophenyl)acetamide
Ambeed provide 14 derivatives of N-(3-fluorophenyl)acetamide.
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—NHC(O)CH3).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Hydrolysis: N-Phenylacetamide can undergo hydrolysis in the presence of an acid or base to yield phenylacetic acid and ammonia or an amine, respectively. The reaction involves breaking the amide bond to form a carboxylic acid group.
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N-(5-Fluoro-4-methoxy-2-nitrophenyl)acetamide