Chemistry
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N-benzylbenzenesulfonamide
Sulfonation: N-Benzylbenzenesulfonamide can be sulfonated using concentrated sulfuric acid or other sulfonating agents. This reaction introduces a sulfonate group (-SO3H) into the compound.
Reductive Amination: It can be used as a starting material in reductive amination reactions. For example, by reacting it with a primary amine and a reducing agent, you can form secondary amines.
Substitution Reactions: N-Benzylbenzenesulfonamide can undergo nucleophilic substitution reactions. For example, you can displace the sulfonamide group with a nucleophile under appropriate conditions.
Hofmann Rearrangement: By treating it with bromine or chlorine followed by aqueous sodium hydroxide, you can perform a Hofmann rearrangement, converting the sulfonamide into an amine.
Nucleophilic Addition: The pyridine ring can undergo nucleophilic addition reactions at the C-2 position with various nucleophiles.
Substitution Reactions on the Pyridine Ring: The pyridine ring can also undergo electrophilic or nucleophilic substitution reactions depending on the reaction conditions.
Metalation: N-Benzylbenzenesulfonamide can be used as a ligand in coordination chemistry reactions with various metal ions.
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(2-(N-Benzylsulfamoyl)-5-methylphenyl)boronic acid
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N-[(4-Fluorophenyl)methyl]benzenesulfonamide
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3-Bromo-N-isopropyl-N-(4-methoxybenzyl)benzenesulfonamide
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N-Benzyl-2-bromo-4-methylbenzenesulfonamide
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4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide
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(3-(N-Isopropyl-N-(4-methoxybenzyl)sulfamoyl)phenyl)boronic acid
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(4-(N-Ethyl-N-(4-methoxybenzyl)sulfamoyl)phenyl)boronic acid
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(4-(N-(4-Methoxybenzyl)sulfamoyl)phenyl)boronic acid
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(4-(N-Butyl-N-(4-methoxybenzyl)sulfamoyl)phenyl)boronic acid
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(4-(N-(4-Methoxybenzyl)-N-methylsulfamoyl)phenyl)boronic acid
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Methyl 2-(4-methylphenylsulfonamido)-2-phenylacetate