Chemistry Heterocyclic Building Blocks Pyridines N-benzylpyridin-2-amine
Ambeed provide 9 derivatives of N-benzylpyridin-2-amine.
These compounds have the same murcko framework: N-benzylpyridin-2-amine.
Alkylation: Similar to acylation, the amine group can be alkylated by using alkyl halides or other alkylating agents. This results in the formation of N-alkylated products.
Reductive Amination: N-Benzylpyridin-2-amine can participate in reductive amination reactions, where it reacts with a carbonyl compound (such as an aldehyde or ketone) and a reducing agent (e.g., sodium borohydride or lithium aluminum hydride) to form secondary or tertiary amines.
Amidation: It can react with carboxylic acid and appropriate activating agents (e.g., DCC or EDC) to form amides.
Heterocycle Formation: Depending on the reaction conditions, N-Benzylpyridin-2-amine may undergo cyclization reactions to form various heterocycles.
Substitution Reactions: The pyridine ring can undergo nucleophilic substitution reactions at various positions, depending on the reagents and conditions.
Dealkylation: The benzyl group can be removed under specific conditions, leading to the formation of the parent pyridine-2-amine.
Condensation Reactions: N-Benzylpyridin-2-amine can participate in condensation reactions with other compounds, leading to the formation of various derivatives.
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(6-(Benzyl(methyl)amino)pyridin-3-yl)boronic acid
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(R)-5-Nitro-N-(1-phenylethyl)pyridin-2-amine
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(S)-5-Nitro-N-(1-phenylethyl)pyridin-2-amine
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N2-(4-Fluorobenzyl)-5-nitropyridine-2,6-diamine