Chemistry Organic Building Blocks Aryls N-cyclopropylbenzenesulfonamide
Ambeed provide 10 derivatives of N-cyclopropylbenzenesulfonamide.
These compounds have the same murcko framework: N-cyclopropylbenzenesulfonamide.
Substitution Reactions: N-cyclopropylbenzenesulfonamide can undergo nucleophilic substitution reactions. For example, it can react with strong nucleophiles, such as Grignard reagents or organolithium compounds, to substitute the sulfonamide group with the incoming nucleophile.
Acylation Reactions: It can undergo acylation reactions with acyl chlorides or anhydrides in the presence of a base to form amides. For instance, reacting it with acyl chloride could lead to the formation of N-cyclopropylbenzenesulfonamide-derived amides.
Reductive Reactions: The sulfonamide group can be reduced using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) to yield the corresponding amine.
Dehydration Reactions: Under specific conditions, it can undergo dehydration reactions to form cyclic compounds or other products. For instance, heating with strong acids can lead to the formation of cyclic products.
Ring-Opening Reactions: Depending on the reaction conditions and reagents, N-cyclopropylbenzenesulfonamide can undergo ring-opening reactions, particularly if the ring-opening is thermodynamically favorable.
Metal-Catalyzed Reactions: It can participate in various transition-metal-catalyzed reactions, such as palladium-catalyzed cross-coupling reactions, to form new carbon-carbon or carbon-heteroatom bonds.
Nucleophilic Aromatic Substitution: In some cases, the aromatic ring may undergo nucleophilic aromatic substitution reactions. This is highly dependent on reaction conditions and the nature of the nucleophile.
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N-(4-(N-Cyclopropylsulfamoyl)phenyl)acetamide
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4-[(Cyclopropylamino)sulfonyl]benzoic Acid
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(3-(N-Cyclopropylsulfamoyl)phenyl)boronic acid
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(4-(N-Cyclopropylsulfamoyl)phenyl)boronic acid
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4-Bromo-N-cyclopropyl-3-methylbenzenesulfonamide