Chemistry
Heterocyclic Building Blocks
Pyrimidines
N-methylpyrimidin-2-amine
Nucleophilic Substitution: The amine group can act as a nucleophile and undergo substitution reactions with electrophiles. For instance, it might react with alkyl halides to form N-methyl-substituted pyrimidines.
Acylation: The amine group can react with acyl chlorides or acid anhydrides to form amides.
Alkylation: The nitrogen atom in the amine group can be alkylated, often under acidic or basic conditions, resulting in the introduction of an alkyl group.
Condensation Reactions: The amine group may participate in condensation reactions, for example, with carbonyl compounds to form imines or with ketones/aldehydes in the presence of ammonia or a primary amine to form pyrimidine derivatives.
Substitution Reactions on the Pyrimidine Ring: The pyrimidine ring might undergo substitution reactions, especially at the C-5 and C-6 positions. For example, these positions might react with electrophiles under suitable conditions.
Reductive Amination: The amine group can potentially undergo reductive amination reactions with carbonyl compounds in the presence of a reducing agent to form secondary amines.
Oxidation: The nitrogen atom in the amine group may be oxidized under certain conditions to form N-oxide or other oxidized products.
Cyclization Reactions: Depending on the conditions, cyclization reactions may occur, leading to the formation of fused or spirocyclic compounds.
Protonation/Deprotonation: The amine group can undergo protonation or deprotonation reactions, depending on the pH of the environment.
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4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine
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(2-(Methylamino)pyrimidin-5-yl)boronic acid
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2-(Methylamino)pyrimidine-5-carboxylic acid