Chemistry Organic Building Blocks Aryls N-phenethylbenzamide
Acylation: N-phenethylbenzamide can undergo acylation reactions, where the amide group (-CONH-) can be modified with acylating agents such as acyl chlorides (e.g., acetyl chloride) or anhydrides to form N-phenethyl-N-acylbenzamides.
Reduction: The carbonyl group (C=O) in the benzamide can be reduced to the corresponding alcohol (C-OH) using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Benzoin Condensation: N-phenethylbenzamide can participate in the benzoin condensation reaction when treated with a suitable catalyst like cyanide ions. This reaction leads to the formation of a β-diketone compound.
Friedel-Crafts Acylation: In the presence of Lewis acids like aluminum chloride (AlCl3), N-phenethylbenzamide can undergo Friedel-Crafts acylation to introduce an acyl group onto the benzene ring.
Amide Hydrolysis: Under acidic or basic conditions, N-phenethylbenzamide can undergo amide hydrolysis to yield N-phenethylbenzoic acid and the corresponding amine.
Substitution Reactions: Depending on the reaction conditions and reagents, the aromatic ring in N-phenethylbenzamide can undergo electrophilic aromatic substitution reactions, such as nitration, halogenation, or sulfonation.
Grignard Reaction: N-phenethylbenzamide can react with Grignard reagents (alkyl or aryl magnesium halides) to form new carbon-carbon bonds.
Oxidation: The phenyl group in N-phenethylbenzamide can be oxidized using strong oxidizing agents to yield benzoic acid or other oxidized products.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Carbon related+−
Formula Weight+−
click to sign in and save
Ethyl (4-(2-(5-chloro-2-methoxybenzamido)ethyl)phenyl)sulfonylcarbamate
click to sign in and save
(4-(Phenethylcarbamoyl)phenyl)boronic acid