Chemistry Heterocyclic Building Blocks Pyridines N-phenylpicolinamide
Ambeed provide 8 derivatives of N-phenylpicolinamide.
These compounds have the same murcko framework: N-phenylpicolinamide.
Nucleophilic Addition: N-phenylpicolinamide can undergo nucleophilic addition reactions at the carbonyl group. For example, with a strong nucleophile like sodium borohydride (NaBH4), it can be reduced to the corresponding alcohol.
Acylation: N-phenylpicolinamide can be acylated at the nitrogen or oxygen atom. For example, reaction with acyl chlorides or anhydrides can lead to the formation of amides.
Reductive Amination: It can undergo reductive amination reactions, where the nitrogen is substituted with an amine group. This reaction usually requires a reducing agent like sodium cyanoborohydride.
Grignard Reaction: N-phenylpicolinamide can react with Grignard reagents, leading to the formation of new carbon-carbon bonds.
Aromatic Substitution: The phenyl group can undergo electrophilic aromatic substitution reactions under suitable conditions.
Heterocyclic Chemistry: It can participate in reactions typical of pyridines or benzamides, leading to the formation of various heterocyclic compounds.
Oxidation: The compound can be oxidized at the benzyl carbon or the nitrogen atom.
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N-(2-Chlorophenyl)-5-(methylsulfonyl)picolinamide