Chemistry Heterocyclic Building Blocks Pyrimidines N2,N4-diphenylpyrimidine-2,4-diamine
Ambeed provide 5 derivatives of N2,N4-diphenylpyrimidine-2,4-diamine.
These compounds have the same murcko framework: N2,N4-diphenylpyrimidine-2,4-diamine.
Substitution Reactions: DPhPD contains amino groups (NH2) in its structure, which can undergo substitution reactions with various electrophiles. For example, you can perform N-acylation or N-alkylation reactions by reacting DPhPD with acylating or alkylating agents.
Oxidation Reactions: Depending on the reaction conditions and reagents used, DPhPD can be oxidized to form various products. Common oxidizing agents like potassium permanganate (KMnO4) or hydrogen peroxide (H2O2) may be employed.
Condensation Reactions: DPhPD can participate in condensation reactions to form various heterocyclic compounds or polymers. For instance, it can be used in the synthesis of polymeric materials or as a building block in the formation of more complex organic compounds.
Metal-Catalyzed Reactions: DPhPD can also participate in metal-catalyzed reactions, particularly with transition metal catalysts. These reactions can lead to the formation of new carbon-nitrogen or carbon-carbon bonds.
Reduction Reactions: The nitro groups in DPhPD can be reduced to amino groups using reducing agents like hydrogen gas H2 in the presence of a catalyst such as palladium on carbon (Pd/C).
Bromination or Chlorination: The aromatic rings in DPhPD can be halogenated by reacting it with bromine (Br2) or chlorine (Cl2) in the presence of a Lewis acid catalyst.
Cross-Coupling Reactions: DPhPD can be used in cross-coupling reactions, such as Suzuki-Miyaura, Heck, or Stille reactions, to form carbon-carbon or carbon-heteroatom bonds.
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