Chemistry
Heterocyclic Building Blocks
Pyridines
nicotinaldehyde
Aldol Condensation: Nicotinaldehyde can undergo aldol condensation reactions with itself or other carbonyl compounds in the presence of a base to form β-hydroxypyridines.
Grignard Reaction: It can react with Grignard reagents (organomagnesium compounds) to form alcohol derivatives. The resulting product depends on the nature of the Grignard reagent used.
Reduction: Nicotinaldehyde can be reduced to the corresponding alcohol, nicotinol, using reducing agents like sodium borohydride or lithium aluminum hydride.
Oxidation: Under appropriate conditions, nicotinaldehyde can be oxidized to nicotinic acid (niacin) or its esters.
Acetylation: Nicotinaldehyde can undergo acetylation with acetic anhydride or acetyl chloride in the presence of a base to form the corresponding acetate ester.
Heterocyclization: It can undergo heterocyclization reactions, especially with amino compounds, to form pyridine derivatives.
Mannich Reaction: Nicotinaldehyde can participate in Mannich-type reactions, where it reacts with formaldehyde and a primary or secondary amine to form β-amino alcohols.
Reactions with Electrophiles/Nucleophiles: Nicotinaldehyde can react with various electrophiles or nucleoph.
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4-Chloro-6-(trifluoromethyl)nicotinaldehyde
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4-Bromo-6-(trifluoromethyl)nicotinaldehyde
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5-(2-Methoxyethoxy)pyridine-3-carbaldehyde
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2-(Dimethylamino)-6-fluoronicotinaldehyde
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tert-Butyl (tert-butoxycarbonyl)(5-formylpyridin-2-yl)carbamate
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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinaldehyde
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5-Bromo-2-(trifluoromethyl)isonicotinaldehyde
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2-Chloro-6-(trifluoromethyl)nicotinaldehyde
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2-Chloro-5-(trifluoromethyl)nicotinaldehyde