Chemistry Heterocyclic Building Blocks Pyridines phenyl(pyridin-2-yl)methanone
Ambeed provide 10 derivatives of phenyl(pyridin-2-yl)methanone.
These compounds have the same murcko framework: phenyl(pyridin-2-yl)methanone.
Nucleophilic Substitution: The pyridine ring can undergo nucleophilic substitution reactions at positions with appropriate leaving groups. For example, you can react it with alkyl halides to form N-alkylpyridinium salts.
Acylation: 2-(pyrrolidin-2-yl)pyridine can undergo acylation reactions, where an acyl group (e.g., acetyl, benzoyl) is introduced at the nitrogen atom of the pyrrolidine ring.
Reduction: You can reduce the carbonyl group (C=O) in the pyridine ring to an alcohol using reducing agents like sodium borohydride or lithium aluminum hydride.
Oxidation: You can oxidize the compound by using oxidizing agents to convert the alcohol or amines to corresponding aldehydes or amides.
Ring-Opening Reactions: The pyrrolidine ring can undergo ring-opening reactions under certain conditions, especially when exposed to strong bases.
Condensation Reactions: You can perform condensation reactions with 2-(pyrrolidin-2-yl)pyridine, for example, by reacting it with carbonyl compounds to form Schiff bases or Mannich bases.
Cross-Coupling Reactions: You can perform cross-coupling reactions with this compound by introducing various substituents using palladium-catalyzed reactions such as Suzuki-Miyaura or Heck reactions.
N-Heterocyclic Carbene (NHC) Complexation: The nitrogen atom in the pyridine ring can form a complex with transition metals, making it a useful ligand for various organometallic reactions.
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2-Bromo-N-(4-bromo-2-picolinoylphenyl)acetamide
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N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide