Chemistry Heterocyclic Building Blocks Pyridines pyridin-2-amine
Ambeed provide 29 derivatives of pyridin-2-amine.
These compounds have the same murcko framework: pyridin-2-amineNucleophilic Substitution: The amino group (-NH2) can undergo nucleophilic substitution reactions, where it displaces a leaving group from the molecule. This could involve substitution at the 2-position or other positions of the pyridine ring.
Acylation: The amino group can undergo acylation reactions, where an acyl group is transferred to the amino nitrogen atom, leading to the formation of amides.
Reductive Amination: The amino group can undergo reductive amination reactions, where it reacts with a carbonyl compound (such as an aldehyde or ketone) in the presence of a reducing agent to form secondary or tertiary amines.
Amidation: The amino group can react with carboxylic acids or their derivatives (such as acyl chlorides, acid anhydrides, or esters) to form amides.
Oxidation: Both the amino group and the trifluoromethyl group are susceptible to oxidation under appropriate conditions. This could lead to the formation of various oxidation products.
Reduction: The trifluoromethyl group or the amino group can undergo reduction reactions, depending on the reagents and conditions used. This could lead to the formation of compounds with different functional groups.
Halogenation: The aromatic ring can undergo halogenation reactions, such as electrophilic aromatic substitution, leading to the introduction of halogen atoms (such as chlorine or bromine) onto the ring.
Catalytic Hydrogenation: Under suitable conditions and with appropriate catalysts, the amino or trifluoromethyl group can undergo hydrogenation reactions to yield saturated derivatives.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
6-Aminopyridin-2-yl carbamimidothioate hydrochloride
Deals click to sign in and save
3-(6-Aminopyridin-3-yl)propanoic acid
click to sign in and save
6-Amino-N,N-dimethylpyridine-3-sulfonamide
click to sign in and save
6-Amino-4-fluoropyridin-3-ol hydrochloride
click to sign in and save
5-(2-(Dimethylamino)ethoxy)pyridin-2-amine
click to sign in and save
6-((Trimethylsilyl)ethynyl)pyridin-2-amine
click to sign in and save
tert-Butyl ((6-aminopyridin-3-yl)methyl)carbamate
click to sign in and save
2-(6-Aminopyridin-2-yl)acetic acid hydrochloride
click to sign in and save
(6-Aminopyridin-3-yl)dimethylphosphine oxide
click to sign in and save
(E)-Ethyl 3-(6-aminopyridin-3-yl)acrylate