Chemistry Heterocyclic Building Blocks Pyridines pyridin-2-ylmethanol
Acetylation: The hydroxyl group can be acetylated using acetic anhydride or acetyl chloride to form the corresponding acetate ester.
Oxidation: The alcohol functionality can be oxidized to form the corresponding aldehyde or carboxylic acid using oxidizing agents like chromic acid (Jones reagent), potassium permanganate, or PCC (pyridinium chlorochromate).
Esterification: Reaction with carboxylic acids or acid chlorides in the presence of a suitable catalyst or acid can lead to the formation of esters.
Nucleophilic substitution: The hydroxyl group can undergo substitution reactions with suitable electrophiles to form substituted products.
Ring-closure reactions: Depending on the reaction conditions and reagents, the pyridine ring can undergo various ring-closure reactions to form cyclic compounds.
Reduction: The alcohol functionality can be reduced to the corresponding alkane using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Condensation reactions: The alcohol functionality can participate in condensation reactions with carbonyl compounds or other suitable reactants to form a variety of compounds such as ethers, imines, or enamines.
Substitution reactions on the pyridine ring: The pyridine ring can undergo substitution reactions at the 2-position or other positions depending on the reagents and conditions, leading to a variety of substituted pyridines.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Heterocyclic related+−
Formula Weight+−
click to sign in and save
(4-(Aminomethyl)pyridin-2-yl)methanol hydrochloride
click to sign in and save
1-(2-(Hydroxymethyl)pyridin-4-yl)ethanone
click to sign in and save
(4-(Difluoromethoxy)pyridin-2-yl)methanol
click to sign in and save
(3-Chloro-5-methoxypyridin-2-yl)methanol
click to sign in and save
(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanol
click to sign in and save
(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)methanol
click to sign in and save
tert-Butyl (2-(hydroxymethyl)pyridin-3-yl)carbamate
click to sign in and save
(5-Chloro-4-(difluoromethoxy)pyridin-2-yl)methanol
click to sign in and save
(5-Chloro-3-fluoropyridin-2-yl)methanol
click to sign in and save
(4-Chloro-5-fluoropyridin-2-yl)methanol
click to sign in and save
(5-Fluoro-3-methylpyridin-2-yl)methanol