Chemistry Heterocyclic Building Blocks Pyridines pyridin-3-amine
Ambeed provide 21 derivatives of pyridin-3-amine.
These compounds have the same murcko framework: pyridin-3-amineAcylation: Pyridin-3-amine can undergo acylation reactions, where an acyl group (-CO-R) replaces the amino hydrogen. This reaction is commonly catalyzed by acyl chlorides or acid anhydrides to yield amides.
Alkylation: The amino group in pyridin-3-amine can be alkylated using alkyl halides or alkyl sulfonates, leading to the substitution of the amino hydrogen with an alkyl group.
Acylation: Pyridin-3-amine can react with acyl chlorides or acid anhydrides to form amides.
Nucleophilic substitution: The amino group can act as a nucleophile in substitution reactions. It can displace other leaving groups in suitable electrophiles, such as alkyl halides or aryl halides.
Reductive amination: Pyridin-3-amine can undergo reductive amination reactions with carbonyl compounds (aldehydes or ketones) and reducing agents like sodium cyanoborohydride to form secondary or tertiary amines.
Diazotization: Pyridin-3-amine can undergo diazotization with nitrous acid to form diazonium salts, which are versatile intermediates in organic synthesis.
Mannich reaction: Pyridin-3-amine can participate in the Mannich reaction, which involves the condensation of an amine, formaldehyde, and a compound containing an acidic proton, typically a carbonyl compound.
Hofmann degradation: Pyridin-3-amine can undergo Hofmann degradation under appropriate conditions to yield primary amines.
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5-Amino-N-butylpyridine-2-carboxamide
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tert-Butyl (5-aminopyridin-2-yl)(methyl)carbamate
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5-(Difluoromethoxy)pyridin-3-amine dihydrochloride
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6-((Trimethylsilyl)ethynyl)pyridin-3-amine