Chemistry Heterocyclic Building Blocks Pyridines pyridin-3-ol
Ambeed provide 13 derivatives of pyridin-3-ol.
These compounds have the same murcko framework: pyridin-3-olSubstitution reactions: The hydroxyl group in pyridin-3-ol can undergo substitution reactions with electrophiles, such as acyl chlorides or acid anhydrides, leading to the formation of esters or amides.
Oxidation reactions: Pyridin-3-ol can be oxidized to form pyridine-3,4-dione (also known as nicotinic acid or niacin) or other oxidized derivatives under appropriate conditions.
Esterification reactions: Pyridin-3-ol can react with carboxylic acids in the presence of acid catalysts to form esters.
Acetylation reactions: The hydroxyl group in pyridin-3-ol can be acetylated with acetic anhydride or acetyl chloride in the presence of a base to yield the corresponding acetyl derivative.
Alkylation reactions: Pyridin-3-ol can undergo alkylation with alkyl halides or alkyl sulfonates in the presence of a base to form alkylated derivatives.
Condensation reactions: Pyridin-3-ol can undergo condensation reactions with carbonyl compounds, such as aldehydes or ketones, to form Schiff bases or other condensed products.
Reduction reactions: Pyridin-3-ol can be reduced to piperidine derivatives under appropriate reaction conditions.
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tert-Butyl (5-chloro-3-hydroxypyridin-2-yl)carbamate