Chemistry Heterocyclic Building Blocks Pyridines pyridin-4-ylmethanamine
Ambeed provide 12 derivatives of pyridin-4-ylmethanamine.
These compounds have the same murcko framework: pyridin-4-ylmethanamineAcylation: The primary amine group can undergo acylation reactions with acyl chlorides or acid acid anhydrides to form amides.
Alkylation/Arylation: The nitrogen atom can be alkylated or arylated using alkyl or aryl halides under suitable conditions, such as using a strong base.
Reductive Amination: The primary amine group can undergo reductive amination with aldehydes or ketones in the presence of reducing agents like sodium cyanoborohydride or hydrogen gas with a metal catalyst.
Substitution Reactions: The pyridine ring can undergo electrophilic aromatic substitution reactions, such as nitration, halogenation, sulfonation, or Friedel-Crafts acylation/alkylation.
Oxidation: The primary amine group can be oxidized to form imines or further to amides or nitriles using oxidizing agents like potassium permanganate or chromic acid.
Heterocyclization: Depending on the reaction conditions and reagents used, it might undergo cyclization reactions to form heterocyclic compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds to form Schiff bases.
Reduction: The pyridine ring can be reduced under certain conditions to form piperidine derivatives.
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(2-Fluoropyridin-4-yl)methanamine dihydrochloride
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(2-Chloropyridin-4-yl)methanamine hydrochloride
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(2-Fluoropyridin-4-yl)methanamine hydrochloride
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(3-Bromopyridin-4-yl)methanamine hydrochloride
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(3-(tert-Butoxy)pyridin-4-yl)methanamine