Chemistry Heterocyclic Building Blocks Pyridines pyridine-2-sulfonamide
Ambeed provide 6 derivatives of pyridine-2-sulfonamide.
These compounds have the same murcko framework: pyridine-2-sulfonamideAcylation: Pyridine-2-sulfonamide can undergo acylation reactions, where an acyl group is introduced onto the nitrogen atom of the sulfonamide group. This can be achieved using acyl chlorides or acid anhydrides in the presence of a base.
Alkylation: The nitrogen atom of the sulfonamide group can be alkylated using alkyl halides or other alkylating agents. This reaction typically requires a base to deprotonate the sulfonamide nitrogen and make it nucleophilic.
Sulfonation: The pyridine ring can undergo sulfonation reactions, introducing a sulfonic acid group onto the ring. This can be achieved using strong sulfurating agents such as sulfuric acid or chlorosulfonic acid.
Reduction: The sulfonamide group can be reduced to the corresponding amine under suitable conditions. Common reducing agents include metal hydrides like lithium aluminum hydride or borohydrides like sodium borohydride.
Substitution reactions: The pyridine ring can undergo various substitution reactions, including electrophilic aromatic substitution, nucleophilic aromatic substitution, and metal-catalyzed cross-coupling reactions.
Cyclization reactions: Depending on the functional groups present in the molecule, pyridine-2-sulfonamide can participate in various cyclization reactions, leading to the formation of heterocyclic compounds.
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