Chemistry Heterocyclic Building Blocks Pyridines pyridine-2-thiol
Ambeed provide 8 derivatives of pyridine-2-thiol.
These compounds have the same murcko framework: pyridine-2-thiolSubstitution Reactions: The thiol group can undergo substitution reactions with various electrophiles, such as alkyl halides or acyl chlorides, leading to the formation of alkylated or acylated derivatives of pyridine-2-thiol.
Oxidation: The thiol group can be oxidized to form disulfides or sulfoxides under appropriate conditions. For example, oxidation with hydrogen peroxide or other oxidizing agents can lead to the formation of disulfides.
Metal Complexation: The pyridine nitrogen can coordinate with metal ions to form metal complexes. This is particularly useful in coordination chemistry and catalysis.
Condensation Reactions: Pyridine-2-thiol can undergo condensation reactions with carbonyl compounds to form thiazolidines or thiazoles.
Ring Closure Reactions: Under certain conditions, pyridine-2-thiol can undergo cyclization reactions to form heterocyclic compounds.
Redox Reactions: Pyridine-2-thiol can participate in redox reactions, either as an oxidizing agent or as a reducing agent, depending on the reaction conditions and the nature of the reactants involved.
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