Chemistry Heterocyclic Building Blocks Pyridines pyridine-3-sulfonic acid
Ambeed provide 6 derivatives of pyridine-3-sulfonic acid.
These compounds have the same murcko framework: pyridine-3-sulfonic acidAcid-Base Reactions: Pyridine-3-sulfonic acid is acidic due to the presence of the sulfonic acid group. It can undergo neutralization reactions with bases to form salts. For example, reacting it with sodium hydroxide (NaOH) would yield sodium pyridine-3-sulfonate and water.
Electrophilic Substitution Reactions: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions. For instance, it can react with electrophiles such as nitronium ion to form nitro derivatives, or with acyl chlorides in the presence of a Lewis acid catalyst to form acylated products.
Nucleophilic Substitution Reactions: The sulfonic acid group can be substituted by nucleophiles under appropriate conditions. For instance, treatment with strong nucleophiles like sodium azide (NaN3) may result in the replacement of the sulfonic acid group with the azide group.
Oxidation Reactions: Pyridine-3-sulfonic acid can undergo oxidation under certain conditions. For example, it may be oxidized to the corresponding sulfone or other oxidation products in the presence of strong oxidizing agents such as potassium permanganate (KMnO4) or hydrogen peroxide (H2O2).
Reduction Reactions: Conversely, it can also be reduced under suitable conditions. Reduction of the sulfonic acid group may yield the corresponding sulfonamide or other reduced products.
Esterification Reactions: Pyridine-3-sulfonic acid can undergo esterification with alcohols in the presence of acid catalysts to form esters.
Condensation Reactions: It may participate in condensation reactions with suitable reactants to form heterocyclic compounds or other condensed products.
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