Chemistry Heterocyclic Building Blocks Pyridines pyrido[2,3-b]pyrazine
Ambeed provide 12 derivatives of pyrido[2,3-b]pyrazine.
These compounds have the same murcko framework: pyrido[2,3-b]pyrazine.
Aromatic Substitution: Pyrido[2,3-b]pyrazine contains two aromatic rings. It can undergo electrophilic aromatic substitution reactions. For example, you can perform halogenation (e.g., bromination or chlorination) or nitration to introduce substituents onto the aromatic rings.
Reduction: Pyrido[2,3-b]pyrazine can be reduced using various reducing agents to form dihydropyrido[2,3-b]pyrazine or even tetrahydropyrido[2,3-b]pyrazine, depending on the reaction conditions. Common reducing agents include hydrogen gas (catalytic hydrogenation), metal hydrides, or catalytic transfer hydrogenation.
Oxidation: Oxidation of pyrido[2,3-b]pyrazine can lead to the formation of various oxidation products, including N-oxides or other oxygen-containing functional groups, depending on the reagents and conditions used.
Arylation: Pyrido[2,3-b]pyrazine can undergo arylation reactions, where an aryl group is introduced onto the aromatic rings. This can be achieved through transition metal-catalyzed coupling reactions such as Suzuki, Heck, or Stille reactions.
Cycloaddition: Pyrido[2,3-b]pyrazine can participate in various cycloaddition reactions, such as Diels-Alder reactions with dienophiles or other pericyclic reactions, which can lead to the formation of complex ring systems.
Alkylation and Acylation: Pyrido[2,3-b]pyrazine can be alkylated or acylated at suitable positions using alkyl halides or acyl chlorides in the presence of appropriate bases or catalysts.
Nucleophilic Substitution: If there are electrophilic sites on the molecule, nucleophilic substitution reactions can occur. For example, if the molecule contains halogen atoms, they can be replaced by nucleophiles like amines or alkoxides.
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