Chemistry Heterocyclic Building Blocks Pyridines pyrido[3,4-b]pyrazine
Ambeed provide 11 derivatives of pyrido[3,4-b]pyrazine.
These compounds have the same murcko framework: pyrido[3,4-b]pyrazine.
Electrophilic Aromatic Substitution (EAS): Pyrido[3,4-b]pyrazine has an aromatic ring system and can undergo EAS reactions. For example, it can react with electrophiles like nitration (adding a nitro group), halogenation (adding halogens like Cl or Br), or sulfonation (adding a sulfonic acid group) to substitute hydrogen atoms on the ring.
Nucleophilic Substitution: If there are suitable leaving groups on the molecule, it can undergo nucleophilic substitution reactions, where a nucleophile replaces the leaving group. Common leaving groups include halides (e.g., Cl, Br), tosylates, and mesylates.
Reduction: Pyrido[3,4-b]pyrazine can be reduced using reducing agents like lithium aluminum hydride (LiAlH4) to yield saturated derivatives.
Oxidation: Oxidizing agents can be used to oxidize pyrido[3,4-b]pyrazine, potentially leading to the formation of various functional groups depending on the reaction conditions.
Acylation and Alkylation: Pyrido[3,4-b]pyrazine can react with acylating agents (such as acyl chlorides) or alkylating agents (such as alkyl halides) in the presence of suitable catalysts to introduce acyl or alkyl groups onto the ring.
Cross-Coupling Reactions: Pyrido[3,4-b]pyrazine can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, to form carbon-carbon or carbon-heteroatom bonds.
Cyclization Reactions: Depending on the functional groups present, pyrido[3,4-b]pyrazine can undergo cyclization reactions to form fused or bridged ring systems.
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5-Chloro-2,3-dimethylpyrido[3,4-b]pyrazine
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5-Chloro-8-fluoropyrido[3,4-b]pyrazine