Chemistry
Heterocyclic Building Blocks
Pyrimidines
pyrido[3,4-d]pyrimidine
Aromatic substitution reactions: Pyrido[3,4-d]pyrimidine contains an aromatic ring, and it can undergo typical electrophilic aromatic substitution reactions such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Reduction: Reduction reactions can be used to reduce the aromatic ring, either partially or fully. For instance, catalytic hydrogenation can be used to reduce the aromatic ring to a saturated piperidine-like structure.
Nucleophilic substitution: If there are suitable leaving groups or electrophilic sites, nucleophilic substitution reactions can occur. For example, the halogen atoms on the ring can undergo nucleophilic substitution reactions with strong nucleophiles.
Functional group interconversion: Various functional groups can be introduced onto the pyrido[3,4-d]pyrimidine ring, including alkyl, aryl, amino, hydroxyl, carbonyl, and more. These reactions can involve the use of appropriate reagents and conditions.
Cyclization reactions: Depending on the reaction conditions and the presence of suitable functional groups, intramolecular cyclization reactions can occur to form fused or bridged ring systems.
Oxidation and reduction: Oxidation reactions can convert certain functional groups to their oxidized counterparts, while reduction reactions can reduce functional groups like nitro groups or carbonyl groups.
Ring-opening reactions: If there are reactive sites within the molecule, it can undergo ring-opening reactions under specific conditions, leading to the formation of open-chain compounds.
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2,4,6-Trichloropyrido[3,4-d]pyrimidine
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2,4,8-Trichloropyrido[3,4-d]pyrimidine
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4-Chloro-6-fluoropyrido[3,4-d]pyrimidine
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4-Chloro-2-methylpyrido[3,4-d]pyrimidine
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4,6-Dichloro-2-methylpyrido[3,4-d]pyrimidine
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4-Chloro-2-(trifluoromethyl)pyrido[3,4-d]pyrimidine
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4-Chloro-6-fluoro-2-methylpyrido[3,4-d]pyrimidine