Chemistry Heterocyclic Building Blocks Pyrimidines pyrimidin-2-ol
Ambeed provide 21 derivatives of pyrimidin-2-ol.
These compounds have the same murcko framework: pyrimidin-2-olAromatic Nucleophilic Substitution: Pyrimidin-2-ol may undergo nucleophilic substitution reactions where the hydroxyl group acts as a nucleophile. This can be facilitated under acidic or basic conditions.
Esterification: The hydroxyl group can participate in esterification reactions with carboxylic acids or acid chlorides to form esters.
Oxidation: The hydroxyl group can be oxidized to a carbonyl group under certain conditions. This might involve the use of oxidizing agents.
Halogenation: Under appropriate conditions, pyrimidin-2-ol could potentially undergo halogenation reactions, where halogen atoms (such as bromine or chlorine) are introduced onto the aromatic ring.
Acylation: Pyrimidin-2-ol may react with acyl chlorides or anhydrides to form acylated derivatives.
Nucleophilic Addition: The nitrogen atoms in the pyrimidine ring can act as nucleophiles in reactions with electrophiles, potentially leading to the introduction of various substituents on the ring.
Substitution Reactions: Substitution reactions, particularly at positions ortho and para to the hydroxyl group, can occur under appropriate conditions.
Metalation: The hydrogen on the nitrogen atoms can potentially be replaced by metal atoms under certain reaction conditions.
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Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate
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Methyl 5-chloro-2-oxo-2,3-dihydropyrimidine-4-carboxylate
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4-Amino-2-hydroxy-5-pyrimidinecarboxylic acid
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4-Amino-2-hydroxypyrimidine-5-carbonitrile
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Ethyl 2-hydroxy-4-methylpyrimidine-5-carboxylate
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Methyl 2,4-dihydroxy-6-methylpyrimidine-5-carboxylate
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Methyl 5-bromo-2-hydroxypyrimidine-4-carboxylate
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5,6-Diaminopyrimidine-2,4-diol xsulfate