Chemistry
Heterocyclic Building Blocks
Pyrimidines
pyrimidin-2-ylmethanamine
Nucleophilic Aromatic Substitution: The pyrimidine ring can undergo nucleophilic aromatic substitution reactions. The amine group can act as a nucleophile, attacking electrophilic positions on the pyrimidine ring.
Alkylation or Acylation: The amine group in pyrimidin-2-ylmethanamine can undergo alkylation or acylation reactions, where it reacts with alkyl halides or acyl halides to form substituted amines or amides, respectively.
Reductive Amination: The amine group can participate in reductive amination reactions, where it reacts with a carbonyl compound (e.g., aldehyde or ketone) in the presence of a reducing agent to form secondary or tertiary amines.
Condensation Reactions: The amine group can participate in condensation reactions with carbonyl compounds to form imines or Schiff bases.
Substitution Reactions: The amine group can undergo substitution reactions with various electrophiles, depending on the reaction conditions.
Amidation Reactions: The amine group can react with acid chlorides, acid anhydrides , or carboxylic acids to form amide bonds through amidation reactions.
Heterocyclization: The compound, being a derivative of a pyrimidine ring, can undergo heterocyclization reactions under specific conditions.
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(5-Fluoropyrimidin-2-yl)methanamine hydrochloride
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(5-Bromopyrimidin-2-yl)methanamine hydrobromide
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Pyrimidin-2-ylmethanamine hydrochloride
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(5-Chloropyrimidin-2-yl)methanamine hydrochloride
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(4-Methylpyrimidin-2-yl)methanamine hydrochloride