Chemistry Heterocyclic Building Blocks Pyrimidines pyrimidin-4-ol
Ambeed provide 25 derivatives of pyrimidin-4-ol.
These compounds have the same murcko framework: pyrimidine
Acid-Base Reactions: The hydroxyl group in pyrimidin-4-ol can act as a weak acid, donating a proton to a base.
Substitution Reactions: The hydroxyl group can undergo substitution reactions, where it may be replaced by another functional group. This can occur under acidic or basic conditions.
Oxidation Reactions: Pyrimidin-4-ol may undergo oxidation reactions, leading to the formation of more highly oxidized products. Oxidizing agents like peroxides or strong acids may be involved.
Esterification: The hydroxyl group can react with carboxylic acids in the presence of acid catalysts to form esters.
Nucleophilic Addition: The electron-rich nature of the pyrimidine ring may make it susceptible to nucleophilic attack. For example, it might react with electrophiles to form adducts.
Condensation Reactions: Pyrimidin-4-ol can participate in condensation reactions, forming larger molecules by eliminating a small molecule (such as water or alcohols).
Metal-Catalyzed Reactions: Metal catalysts may facilitate various reactions involving pyrimidin-4-ol, such as coupling reactions or redox processes.
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6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol