Chemistry Heterocyclic Building Blocks Pyrimidines pyrimidine-2,4-diamine
Ambeed provide 14 derivatives of pyrimidine-2,4-diamine.
These compounds have the same murcko framework: pyrimidine-2,4-diamineNucleophilic Substitution Reactions: The amino groups in pyrimidine-2,4-diamine can act as nucleophiles in substitution reactions. For example, they may react with electrophiles (compounds that accept electrons) such as alkyl halides or acyl chlorides.
Acylation Reactions: The amino groups can react with acyl chlorides or anhydrides to form amides. This type of reaction is known as acylation and can lead to the introduction of acyl groups to the amino groups.
Diazo Coupling: Pyrimidine-2,4-diamine can undergo diazo coupling reactions, particularly with diazonium salts. This reaction can lead to the formation of azo compounds.
Condensation Reactions: The amino groups in pyrimidine-2,4-diamine may participate in condensation reactions with carbonyl compounds, leading to the formation of imines or Schiff bases.
Metal Complex Formation: The amino groups can coordinate with metal ions, forming metal complexes.
Oxidation Reactions: Pyrimidine-2,4-diamine may undergo oxidation reactions, especially at the amino groups, to form various oxidation products.
Cyclization Reactions: Depending on the reaction conditions and reagents, pyrimidine-2,4-diamine may undergo cyclization reactions to form fused ring systems or other cyclic compounds.
Polymerization: Under certain conditions, pyrimidine-2,4-diamine can participate in polymerization reactions, especially when treated with suitable reagents or catalysts.
Hydrogenation: The unsaturated bonds in the pyrimidine ring may be subject to hydrogenation under appropriate conditions.
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2,4-diaminopyrimidin-5-ol dihydrochloride
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Ethyl 2,4-diaminopyrimidine-5-carboxylate