Chemistry Heterocyclic Building Blocks Pyrimidines pyrimidine-2-thiol
Ambeed provide 6 derivatives of pyrimidine-2-thiol.
These compounds have the same murcko framework: pyrimidine-2-thiolNucleophilic Substitution Reactions: The sulfur atom in the thiol group can act as a nucleophile, participating in nucleophilic substitution reactions. It can react with electrophiles, such as alkyl halides or other suitable electrophilic reagents.
Oxidation Reactions: The thiol group is susceptible to oxidation, leading to the formation of disulfides. Common oxidizing agents like hydrogen peroxide or elemental iodine can be used for this purpose.
Condensation Reactions: Pyrimidine-2-thiol can undergo condensation reactions with carbonyl compounds (aldehydes or ketones) to form thiazole derivatives.
Metal Complexation: The sulfur atom in the thiol group can coordinate with metal ions, forming metal-thiol complexes.
Substitution Reactions: The hydrogen at the C-5 position of the pyrimidine ring can undergo substitution reactions under certain conditions.
Alkylation: The pyrimidine ring can undergo alkylation reactions where alkyl groups are introduced to the nitrogen atoms in the pyrimidine ring.
Cyclization Reactions: Depending on the reaction conditions, pyrimidine-2-thiol can participate in cyclization reactions to form fused ring systems.
Halogenation: The hydrogen atoms on the pyrimidine ring may be susceptible to halogenation reactions.
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4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol
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4,5-Diamino-6-hydroxy-2-mercaptopyrimidine