Chemistry Heterocyclic Building Blocks Pyrimidines pyrimidine-4,6(1H,5H)-dione
Ambeed provide 3 derivatives of pyrimidine-4,6(1H,5H)-dione.
These compounds have the same murcko framework: pyrimidine-4,6(1H,5H)-dione.
Hydrolysis: Uracil can undergo hydrolysis in the presence of strong acids or bases to yield its corresponding acid or base form. In acidic conditions, it can be converted to uracil-1-acetic acid, while in basic conditions, it can be deprotonated to form uracil-1-olate.
Alkylation: Uracil can react with alkyl halides or alkylating agents to form alkylated uracil derivatives. For example, reaction with methyl iodide can yield 5-methyluracil.
Nucleophilic Substitution: The nitrogen atoms in uracil can act as nucleophiles in reactions with electrophiles. For instance, they can react with various electrophiles to form substituted uracil derivatives.
Oxidation: Uracil can be oxidized under certain conditions to form various oxidation products, such as uracil-6-yl, 5-hydroxyuracil, or uracil-5-carboxylic acid.
Reduction: Uracil can be reduced to form dihydrouracil using reducing agents like sodium borohydride.
Condensation Reactions: Uracil can participate in condensation reactions with other compounds. For example, it can condense with ribose to form uridine, which is a nucleoside.
Metal-Catalyzed Reactions: Uracil can undergo various reactions when catalyzed by transition metal complexes. For example, it can undergo C-H activation or cross-coupling reactions.
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2-(Methylthio)pyrimidine-4,6(1H,5H)-dione
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2-Amino-5-methylpyrimidine-4,6(1H,5H)-dione