Chemistry Heterocyclic Building Blocks Pyrimidines pyrimidine-5-carbaldehyde
Ambeed provide 38 derivatives of pyrimidine-5-carbaldehyde.
These compounds have the same murcko framework: pyrimidine
Nucleophilic Addition: Pyrimidines-5-carbaldehyde can undergo nucleophilic addition reactions with nucleophiles, such as amines or hydrazines, to form corresponding imine or hydrazone derivatives.
Aldol Reaction: The aldehyde group in Pyrimidines-5-carbaldehyde can participate in aldol condensation reactions with other carbonyl compounds, leading to the formation of β-hydroxy-Pyrimidines derivatives.
Reduction: The aldehyde group is susceptible to reduction reactions, typically using reducing agents such as sodium borohydride or lithium aluminum hydride, to produce Pyrimidines-5-methanol or related reduced products.
Oxidation: Pyrimidines-5-carbaldehyde can undergo oxidation reactions, converting the aldehyde group to a carboxylic acids or other oxidized derivatives, depending on the oxidizing agent and conditions.
Mannich Reaction: Reaction with amines and formaldehyde can lead to Mannich-type products, incorporating an alkylamine group.
Vilsmeier-Haack Reaction: Pyrimidines-5-carbaldehyde can react with the Vilsmeier-Haack reagent (DMF and POCl3) to form a reactive intermediate, which can then undergo various transformations.
Metal-Catalyzed Reactions: Transition metal-catalyzed reactions, such as palladium-catalyzed coupling reactions, may be employed to introduce aryl or alkyl groups at different positions of the pyrimidine ring.
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2-Aminopyrimidine-5-carbaldehyde hydrate
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2-(Ethylthio)pyrimidine-5-carbaldehyde
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2-Amino-4-(trifluoromethyl)pyrimidine-5-carbaldehyde
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4,6-Dimethoxypyrimidine-5-carbaldehyde
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4-Chloro-2,6-dimethoxypyrimidine-5-carbaldehyde
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2-Amino-4,6-dichloropyrimidine-5-carboxaldehyde
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4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde
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4-Amino-2,6-dichloropyrimidine-5-carbaldehyde
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4-Methyl-2-(methylthio)pyrimidine-5-carbaldehyde
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4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde
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2-(Dimethylamino)pyrimidine-5-carbaldehyde
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4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde
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4-Amino-2-chloropyrimidine-5-carbaldehyde
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4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde
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2-Chloro-4-(methylamino)pyrimidine-5-carbaldehyde
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4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
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4,6-Dichloro-2-(methylthio)-5-formylpyrimidine
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2,4-Diamino-6-hydroxypyrimidine-5-carbaldehyde
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2-(Trifluoromethyl)pyrimidine-5-carbaldehyde
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4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
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2-Methylsulfanyl-pyrimidine-5-carbaldehyde
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4-Amino-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde