Chemistry Heterocyclic Building Blocks Pyrrolidines pyrrolidine-2-carboxamide
Ambeed provide 12 derivatives of pyrrolidine-2-carboxamide.
These compounds have the same murcko framework: pyrrolidine-2-carboxamideN-Acylation: The nitrogen atom in the pyrrolidine ring can undergo acylation reactions to form N-acyl derivatives.
Alkylation: The nitrogen atom can be alkylated by reaction with alkyl halides or sulfonates.
Substitution Reactions: The nitrogen atom can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution.
Reduction: The carbonyl group can be reduced to form the corresponding amine.
Condensation Reactions: It can participate in condensation reactions to form cyclic compounds or larger molecules.
Ring-opening Reactions: The pyrrolidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Oxidation: The amine group can be oxidized under certain conditions.
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tert-Butyl (2S,4S)-2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate
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tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate
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(R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate
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(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide
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tert-Butyl (2R,4R)-2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate
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(2S,4R)-tert-Butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate