Chemistry Heterocyclic Building Blocks Piperidines spiro[indoline-3,4'-piperidine]

spiro[indoline-3,4'-piperidine]

Ambeed provide 5 derivatives of spiro[indoline-3,4'-piperidine].

These compounds have the same murcko framework: spiro[indoline-3,4'-piperidine].

Nucleophilic Substitution: If there are suitable leaving groups on the indoline or piperidine rings (e.g., halogens or tosylates), nucleophilic substitution reactions can occur. For example, you can perform a nucleophilic substitution using a strong nucleophile like sodium or potassium amide to replace the leaving group.
Acylation and Alkylation: You can perform acylation and alkylation reactions on the nitrogen atoms of the indoline or piperidine rings. For instance, you can react the compound with acyl chlorides or alkyl halides in the presence of a base or catalyst to introduce acyl or alkyl groups, respectively.
Reduction: The rings in this compound contain nitrogen atoms that can be reduced using various reducing agents like hydrogen gas over a metal catalyst, sodium borohydride, or lithium aluminum hydride to form the corresponding amines.
Oxidation: If there are oxidizable groups or substituents in the molecule, you can perform oxidation reactions to convert them into more oxidized functional groups. Common oxidizing agents include potassium permanganate (KMnO4), chromium(VI) reagents, or peracids.
Cyclization: Given the unique structure of the compound, intramolecular cyclization reactions might be possible under certain conditions. These reactions can lead to the formation of complex cyclic compounds.
Hydrolysis: Under acidic or basic conditions, ester or amide bonds within the molecule can undergo hydrolysis reactions to yield the corresponding carboxylic acids or amines.
Ring Opening: Depending on the reaction conditions and the presence of functional groups, ring-opening reactions of either the indoline or piperidine ring may be possible.

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Framework+−

(9H-fluoren-9-yl)methyl piperidine-1-carboxylate (E)-N-(3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (R)-2-phenylpiperidine (R)-3-aminopiperidin-2-one (R)-N-(piperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (S)-2-phenylpiperidine (S)-N-phenylpiperidine-2-carboxamide 1,3-dihydrospiro[indene-2,4'-piperidine] 1,4'-bipiperidine 1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 1-(methylsulfonyl)piperidine 1-(phenylsulfonyl)piperidine 1-(piperidin-1-yl)ethan-1-one 1-(piperidin-4-yl)piperazine 1-benzyl 3-methyl piperidine-1,3-dicarboxylate 1-benzyl-N-methylpiperidin-3-amine 1-benzylpiperidin-3-one 1-benzylpiperidin-4-amine 1-benzylpiperidin-4-one 1-isopropylpiperidine 1-methyl-4-phenylpiperidine 1-methylpiperidin-2-one 1-oxa-8-azaspiro[4.5]decane 1-phenylpiperidin-2-one 2,2-dimethylpiperidin-4-one 2,2-dimethylpiperidine 2,7-diazaspiro[3.5]nonane 2,8-diazaspiro[4.5]decan-3-one 2,8-diazaspiro[4.5]decane 2-(piperidin-1-yl)ethan-1-amine 2-(piperidin-1-yl)ethan-1-ol 2-(piperidin-1-yl)pyridine 2-(piperidin-1-yl)pyrimidine 2-(piperidin-2-yl)ethan-1-ol 2-(piperidin-4-yl)ethan-1-ol 2-(piperidin-4-yl)pyridine 2-methylpiperidin-4-one 2-methylpiperidine 2-phenylpiperidine 3,3-difluoropiperidin-4-one 3,3-difluoropiperidine 3,3-dimethylpiperidin-4-one 3,3-dimethylpiperidine 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(piperidin-1-yl)pyridine 3-(piperidin-4-yl)-1H-indazole 3-(piperidin-4-yl)-1H-indole 3-(piperidin-4-yl)pyridine 3-fluoropiperidin-4-one 3-fluoropiperidine 3-methoxypiperidine 3-methylpiperidin-4-one 3-methylpiperidine 3-phenylpiperidine 4,4-difluoropiperidine 4-(1H-pyrazol-1-yl)piperidine 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine 4-(azetidin-1-yl)piperidine 4-(piperidin-1-yl)pyrimidine 4-(pyrrolidin-1-yl)piperidine 4-benzylpiperidine 4-hydrazineylpiperidine 4-hydroxypiperidin-2-one 4-methyl-1-phenylpiperidine 4-methylenepiperidine 4-oxopiperidine-2-carboxylic acid 4-phenylpiperidin-4-ol 5-hydroxypiperidin-2-one 6-azaspiro[2.5]octane 6-oxopiperidine-2-carboxylic acid 7-azaspiro[3.5]nonane azepane benzyl (R)-3-aminopiperidine-1-carboxylate benzyl 3-hydroxypiperidine-1-carboxylate benzyl 4-oxopiperidine-1-carboxylate benzyl piperidin-4-ylcarbamate benzyl piperidine-1-carboxylate benzyl-3-aminopiperidine-1-carboxylate ethyl piperidine-1-carboxylate ethyl piperidine-2-carboxylate ethyl piperidine-3-carboxylate ethyl piperidine-4-carboxylate methyl 4-oxopiperidine-2-carboxylate methyl piperidine-2-carboxylate methyl piperidine-3-carboxylate N-benzylpiperidin-4-amine N-methylpiperidin-3-amine N-phenylpiperidin-4-amine N-phenylpiperidine-2-carboxamide phenyl(piperidin-1-yl)methanone phenyl(piperidin-4-yl)methanone piperidin-2-ylmethanamine piperidin-2-ylmethanol piperidin-3-amine piperidin-3-ol piperidin-3-one piperidin-3-ylmethanamine piperidin-3-ylmethanol piperidin-4-amine piperidin-4-ol piperidin-4-ylmethanamine piperidin-4-ylmethanol piperidine-2,4-dione piperidine-2,6-dione piperidine-2-carboxylic acid piperidine-3-carboxamide piperidine-3-carboxylic acid piperidine-4-carboxylic acid quinuclidine spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one spiro[chromane-2,4'-piperidin]-4-one spiro[indene-2,4'-piperidin]-1(3H)-one spiro[indoline-3,4'-piperidin]-2-one spiro[indoline-3,4'-piperidine] tert-butyl (2-oxopiperidin-3-yl)carbamate tert-butyl (6-oxopiperidin-3-yl)carbamate tert-butyl (piperidin-3-ylmethyl)carbamate tert-butyl 2-oxopiperidine-1-carboxylate tert-butyl 3-bromopiperidine-1-carboxylate tert-butyl 4-oxopiperidine-1-carboxylate tert-butyl 4-phenoxypiperidine-1-carboxylate tert-butyl 4-phenylpiperidine-1-carboxylate tert-butyl piperidin-3-ylcarbamate

By Key Group+−

1,2,2,6,6-pentamethylpiperidine 2,2,6,6-tetramethyl-1-piperidinyloxy free radical 2,2,6,6-tetramethylpiperidine acetylpiperidine aminopiperidine benzoylpiperidine benzylpiperidine bipiperidine boc-piperidine boronate-piperidine-carboxylate bromopiperidine carbamoylpiperidine chloropiperidine cyanopiperidine cyclopropylpiperidin difluoromethyl-piperidine difluoropiperidine dimethylpiperidine dioxaborolane-piperidine dioxopiperidine ethylpiperidine ethynylpiperidine fluoropiperidine formylpiperidine hydroxyethyl-piperidine-carboxylate hydroxymethyl-piperidine-carboxylate hydroxypiperidine isopropylpiperidine methoxypiperidine methylenepiperidine methylpiperidine oxoethyl-piperidine-carboxylate oxopiperidine pentamethylpiperidin phenoxypiperidine phenyl-sulfonyl-piperidine phenylpiperidine piperidin-amine piperidin-imidazolyl Piperidine Derivatives piperidine-benzimidazole piperidine-benzofuran piperidine-carboxylate piperidine-carboxylate-hydrochloride piperidine-carboxylic acid piperidine-ethanol piperidine-hydrochloride piperidine-indole piperidine-methanamine piperidine-methanone piperidine-nitrile piperidine-piperidine piperidine-propanol piperidine-pyrimidine piperidine-triazole piperidineacetic piperidinecarboxylate piperidinecarboxylic piperidinemethanol piperidinone piperidinyl-phenyl-boronic acid/ester propylpiperidine pyrazole-piperidine pyridin-piperidine spiro-benzofuran-piperidine spiro-indoline-piperidine tetrahydropyrazolopyridine tetramethylpiperidine trifluoromethyl-phenyl-piperidine trifluoromethyl-piperidine

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By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Azoes Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydroxylamines Iodides Ketones Nitriles Nitroes Organoboron Oximes Phenols Phosphoruses Sulfamides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Thioureas Trifluoromethyls Ureas

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    sp3-Atoms+−

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    By Configuration+−

    1'-Methylspiro[indoline-3,4'-piperidine]

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    A28478569584-91-495%

    1'-Methylspiro[indoline-3,4'-piperidine]

    $442.00/1g

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    tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

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    A158118167484-91-596%

    tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

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    tert-Butyl 5-chlorospiro[indoline-3,4'-piperidine]-1'-carboxylate

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    A165090637362-21-195%

    tert-Butyl 5-chlorospiro[indoline-3,4'-piperidine]-1'-carboxylate

    $123.00/250mg

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    tert-Butyl spiro[indoline-3,4'-piperidine]-1'-carboxylate

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    A524818180465-84-395%

    tert-Butyl spiro[indoline-3,4'-piperidine]-1'-carboxylate

    $92.00/1g

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    1'-(tert-Butoxycarbonyl)spiro[indoline-3,4'-piperidine]-5-carboxylic acid

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    A535750888222-12-698%

    1'-(tert-Butoxycarbonyl)spiro[indoline-3,4'-piperidine]-5-carboxylic acid

    $595.00/1g

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