Chemistry Heterocyclic Building Blocks Pyridines tert-butyl (2-chloropyridin-4-yl)carbamate
Ambeed provide 4 derivatives of tert-butyl (2-chloropyridin-4-yl)carbamate.
These compounds have the same murcko framework: tert-butyl (2-chloropyridin-4-yl)carbamateSubstitution Reactions: The chlorine atom in the 2-chloropyridine moiety can undergo substitution reactions with various nucleophiles, such as amines, alcohols, or thiols. This could lead to the formation of substituted pyridine derivatives.
Dehydrochlorination: Under basic conditions, tert-butyl (2-chloropyridin-4-yl)carbamate may undergo dehydrochlorination to form an unsaturated compound. This could involve the removal of HCl from the molecule, resulting in the formation of an alkene.
Acylation: The carbamate group can act as a nucleophile in acylation reactions, particularly under acidic conditions, leading to the formation of amides or esters.
Reduction: The carbamate group or the pyridine ring could undergo reduction reactions under appropriate conditions, resulting in the formation of corresponding reduced products.
Cross-coupling Reactions: The pyridine ring can participate in various cross-coupling reactions, such as Suzuki, Heck, or Stille coupling, leading to the formation of biaryl or heteroaryl compounds.
Cyclization Reactions: Under certain conditions, tert-butyl (2-chloropyridin-4-yl)carbamate may undergo intramolecular cyclization reactions, leading to the formation of cyclic compounds.
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tert-Butyl (2-chloro-3-(2-hydroxyethyl)pyridin-4-yl)carbamate
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tert-Butyl (2-chloro-5-methylpyridin-4-yl)carbamate
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tert-Butyl (2-chloro-5-fluoropyridin-4-yl)carbamate