Chemistry Heterocyclic Building Blocks Pyridines tert-butyl pyridin-3-ylcarbamate
Ambeed provide 16 derivatives of tert-butyl pyridin-3-ylcarbamate.
These compounds have the same murcko framework: tert-butyl pyridin-3-ylcarbamateDeprotection: Removal of the tert-butyl pyridin-3-ylcarbamate protecting group to reveal the free amine. This can be achieved using various methods such as acid-catalyzed hydrolysis or treatment with nucleophiles.
Substitution reactions: The tert-butyl pyridin-3-ylcarbamate group can undergo substitution reactions with nucleophiles. For example, nucleophilic substitution at the carbamate carbon or at the pyridine ring can occur.
Metal-catalyzed reactions: Tert-butyl pyridin-3-ylcarbamate can participate in metal-catalyzed reactions such as cross-coupling reactions, where the pyridine nitrogen or the carbamate carbon can serve as the site for metal coordination.
Functional group transformations: The carbamate functionality and the tert-butyl group can undergo various functional group transformations, such as oxidation, reduction, or addition reactions.
Cyclization reactions: Depending on the structure of the molecule, tert-butyl pyridin-3-ylcarbamate can participate in cyclization reactions to form heterocycles.
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5-((tert-Butoxycarbonyl)amino)nicotinic acid
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tert-Butyl (2-bromopyridin-3-yl)carbamate
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tert-Butyl N-(5-hydroxypyridin-3-yl)carbamate
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tert-Butyl (5-ethynylpyridin-3-yl)carbamate
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tert-Butyl (2-methylpyridin-3-yl)carbamate
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tert-Butyl (6-methylpyridin-3-yl)carbamate
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tert-Butyl (2-methoxypyridin-3-yl)carbamate
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Methyl 5-((tert-butoxycarbonyl)amino)picolinate
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(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester
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tert-Butyl (4-formylpyridin-3-yl)carbamate
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Methyl 3-((tert-butoxycarbonyl)amino)picolinate
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tert-Butyl (4-iodo-2-methoxypyridin-3-yl)carbamate
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tert-Butyl (6-acetylpyridin-3-yl)carbamate