Chemistry Heterocyclic Building Blocks Pyrimidines tetrahydropyrimidin-2(1H)-one
Ambeed provide 6 derivatives of tetrahydropyrimidin-2(1H)-one.
These compounds have the same murcko framework: tetrahydropyrimidin-2(1H)-one.
Acid-Catalyzed Hydrolysis: Tetrahydropyrimidin-2(1H)-one can be hydrolyzed under acidic conditions to produce the corresponding carboxylic acid and amine.
Base-Catalyzed Hydrolysis: Under basic conditions, the compound can undergo hydrolysis to form the carboxylate anion and amine.
Nucleophilic Addition Reactions: The carbonyl group in tetrahydropyrimidin-2(1H)-one can undergo nucleophilic addition reactions with various nucleophiles, such as Grignard reagents, amines, and hydride donors.
Acylation: Tetrahydropyrimidin-2(1H)-one can be acylated at the nitrogen or oxygen atom with acyl halides or anhydrides to form amides or esters, respectively.
Ring Opening Reactions: Depending on the reaction conditions and reagents, the ring structure can be cleaved, leading to the formation of open-chain compounds.
Substitution Reactions: The nitrogen atom in the ring can undergo substitution reactions with various electrophiles.
Tautomerism: The compound can exist in different tautomeric forms, leading to possible tautomeric interconversions.
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5-(Hydroxymethyl)tetrahydropyrimidin-2(1H)-one
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(S)-3-Methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoic acid