Chemistry Heterocyclic Building Blocks Pyridines thieno[2,3-b]pyridine
Ambeed provide 22 derivatives of thieno[2,3-b]pyridine.
These compounds have the same murcko framework: thieno[2,3-b]pyridine.
Aromatic Electrophilic Substitution: Thieno[2,3-b]pyridine can undergo electrophilic substitution reactions, similar to other aromatic compounds. For example, it can react with electrophiles like acyl chlorides, nitration reagents, or Friedel-Crafts reagents to introduce substituents onto the aromatic ring.
Nucleophilic Aromatic Substitution: Thieno[2,3-b]pyridine can undergo nucleophilic aromatic substitution reactions, where nucleophiles can replace substituents on the ring. This is often more challenging due to the electron-deficient nature of the heteroaromatic ring, but it's possible.
Reduction: Thieno[2,3-b]pyridine can be reduced using various reducing agents to yield saturated or partially saturated derivatives.
Oxidation: Thieno[2,3-b]pyridine can be oxidized using strong oxidizing agents to introduce functional groups or convert it into other compounds.
Halogenation: Thieno[2,3-b]pyridine can undergo halogenation reactions with halogenating agents to introduce halogen substituents onto the aromatic ring.
Cross-Coupling Reactions: Thieno[2,3-b]pyridine can be used as a substrate in various cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, to form carbon-carbon or carbon-heteroatom bonds.
Ring-Opening Reactions: Depending on the reaction conditions and reagents, thieno[2,3-b]pyridine can undergo ring-opening reactions to form different open-chain compounds.
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Ethyl 4-chlorothieno[2,3-b]pyridine-5-carboxylate
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Thieno[2,3-b]pyridine-2-carboxylic acid
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6-Chlorothieno[2,3-b]pyridine-2-carbaldehyde
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Methyl 3-aminothieno[2,3-b]pyridine-2-carboxylate
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3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylic acid
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4-Chlorothieno[2,3-b]pyridine-2-carboxylic acid
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Ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate
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3-Amino-6-methylthieno[2,3-b]pyridine-2-carboxylic acid
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3-Aminothieno[2,3-b]pyridine-2-carboxylic acid
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4,6-Dichloro-2-methylthieno[2,3-b]pyridine
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Ethyl 3-chlorothieno[2,3-b]pyridine-2-carboxylate