Chemistry Heterocyclic Building Blocks Pyridines thieno[3,2-b]pyridine
Ambeed provide 18 derivatives of thieno[3,2-b]pyridine.
These compounds have the same murcko framework: thieno[3,2-b]pyridine.
Substitution Reactions: Thieno[3,2-b]pyridine can undergo electrophilic aromatic substitution reactions. For example, you can perform halogenation (e.g., bromination or chlorination) by treating it with a halogen source in the presence of a Lewis acid catalyst.
Nucleophilic Substitution: If thieno[3,2-b]pyridine contains appropriate leaving groups, it can undergo nucleophilic substitution reactions. For instance, nucleophiles like amines or alkoxides can replace the leaving groups.
Reduction: Thieno[3,2-b]pyridine can be reduced using reducing agents such as lithium aluminum hydride (LiAlH4) to form saturated derivatives.
Oxidation: Oxidation reactions can convert thieno[3,2-b]pyridine to its corresponding oxidized products. This can be achieved using oxidizing agents like potassium permanganate (KMnO4) or chromium(VI) reagents.
Functional Group Transformations: Depending on the functional groups present, you can perform various reactions like acylation, alkylation, esterification, and more. For example, you can react thieno[3,2-b]pyridine with acyl chlorides or acid anhydrides to introduce acyl groups.
Cross-Coupling Reactions: Thieno[3,2-b]pyridine can be used in cross-coupling reactions, such as Suzuki coupling, Stille coupling, or Heck reaction, to form C-C or C-X bonds with other compounds.
Cyclization Reactions: If thieno[3,2-b]pyridine has suitable functional groups, it can undergo cyclization reactions to form complex ring systems.
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5-Chloro-7-methoxythieno[3,2-b]pyridine
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7-Chloro-6-nitrothieno[3,2-b]pyridine
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3-Bromothieno[3,2-b]pyridine-2-carbaldehyde