Inhibitors/Agonists PI3K/Akt/mTOR Akt

Akt

Akt, also known as protein kinase B (PKB), is a serine/threonine kinase that depends on serum and lipids, including three family members: Akt1, Akt2, and Akt3. They consist of a pleckstrin homology (PH) domain, a kinase domain, and a regulatory domain. Akt is widely distributed in cells, mainly in the cytoplasm, where it regulates processes such as cell survival, proliferation, growth, metabolism, and apoptosis by phosphorylating various substrates. Activation of Akt involves the PI3K/Akt signaling pathway, which is a crucial pathway for cells to respond to external signals. Aberrant specific expression and activity of Akt genes are associated with various diseases, including cancer, diabetes, and cardiovascular diseases. Regulation of the Akt pathway is important for understanding cell fate and disease treatment.