Pharmaceutical Intermediates Antineoplastics Amifostine

Amifostine

Amifostine (WR2721) functions as a broad-spectrum cytoprotective and radioprotective agent. It specifically shields normal tissues from harm induced by radiation and chemotherapy, while also acting as a potent inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Moreover, it defends cells from damage by neutralizing oxygen-derived free radicals and mitigates renal toxicity while exhibiting antiangiogenic properties.

CAS: 20537-88-6

Formula: C₅H₁₅N₂O₃PS

Molecular Weight: 214.22

Target: HIF-α1