ATAD5 (ATPase family AAA domain-containing protein 5) is a member of the AAA+ ATPase family, crucial for polymerase exchange and maintaining the stability of replication forks during DNA replication. It features a typical ATPase AAA domain. ATAD5 is localized in the nucleus and primarily involved in DNA replication and repair processes. The gene is expressed in various cell types, with expression levels associated with cell cycle stages. Mutations or functional abnormalities in ATAD5 are linked to chromosomal instability and an increased risk of tumorigenesis.